Bakhtisho’ hailed from the Syriac Bakhtisho’ Family, which practiced medicine in Baghdad for nearly four decades. He worked as a doctor for the Abbasid Calpih Al-Motaki Le-Amr El-Lah (1134-1160 AD), serving among other doctors including Ali bin Al-Rahiba, Anosh and Thabit bin Sinan bin Thabit.